作者报告了一例罕见的胎儿多发性颅内胎儿，符合威利斯的传统标准，其中包括轴向和阑尾骨骼与周围有组织的组织。这个病例是确定从研究一个足月女婴谁提出脑室肿大。CT扫描显示颅内钙化，提示中轴骨。出生体重3.176 kg(第50 - 75百分位)，身高52 cm(第90百分位)，头围35 cm(第50 - 75百分位)，1分钟和5分钟时Apgar评分分别为7分和8分。在第12周第5天和第19周第6天进行的产前超声检查显示正常。37周产前超声检查显示脑室肿大和梗阻性脑积水，可能有颅内畸胎瘤。出生时的超声、CT、磁共振成像和磁共振血管造影显示2个复杂的脑室内肿块，包括囊性、实性和骨性成分。在3个月大时进行开颅手术切除肿块。婴儿活了下来，现在12个月大，有一些发育进展。两根中轴骨，伴肋骨和四肢，包括形态良好的脚和脚趾。 Both anencephalic structures had skin with hair, fat, skeletal and smooth muscle, and bony structures with bone marrow and focal areas of calcification. Multiple viscera were present and included thymus, bowel, stomach, salivary gland, kidney, adrenal gland, lung, and presumed adnexal structures. A diagnosis of fetuses in fetu was rendered. Chromosomal studies of the child and tissue from the 2 fetuses in fetu showed normal female karyotypes. A single nucleotide polymorphism array analysis from the proband infant and tissue from the 2 identified fetuses in fetu appeared to be genetically identical. These results are consistent with a monozygotic twin embryonic origin of the fetus in fetu tissue, which is a mechanism that has been suggested in previous reports in which karyotypes, blood types, and limited genetic loci have been studied. This is the first report of a rare example of intracranial intraventricular twin fetuses in fetu for which a genome-wide single nucleotide polymorphism assay has confirmed their genetic identity.
