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Immunohistochemical expression of human chorionic gonadotropin and P-glycoprotein in human pituitary glands and craniopharyngiomas

Osamu Tachibana Department of Neurosurgery, University of Kanazawa School of Medicine, Takaramachi, Kanazawa City, Japan

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Tetsumori Yamashima Department of Neurosurgery, University of Kanazawa School of Medicine, Takaramachi, Kanazawa City, Japan

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Junkoh Yamashita Department of Neurosurgery, University of Kanazawa School of Medicine, Takaramachi, Kanazawa City, Japan

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Yasushi Takabatake Department of Neurosurgery, University of Kanazawa School of Medicine, Takaramachi, Kanazawa City, Japan

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✓ In order to clarify the cellular origin of craniopharyngiomas, the authors examined the distribution of P-glycoprotein (PGP) and human chorionic gonadotropin (HCG) in five normal adenohypophyses and in 23 craniopharyngiomas using peroxidase immunohistochemistry. The correlation between the expression of PGP in craniopharyngiomas and the recurrence of these tumors was also investigated. A number of pars intermedia cyst-lining cells immunostained positively for anti-PGP antibodies. A small number of adenohypophysial cells were also positive for PGP, but squamous epithelial nests were negative in all samples. However, HCG-βwas consistently demonstrated in adenohypophysial cells, pars intermedia cyst-lining cells, and squamous epithelial nests. In 11 craniopharyngiomas, the apical portion of cuboidal cells and some polygonal cells immunostained positively with anti-PGP antibodies. In four HCG-producing craniopharyngiomas, a large number of tumor cells were immunostained with anti-PGP antibodies, three of which showed a recurrence of cystic tumors. By double labeling, the coexpression of HCG-βand PGP was demonstrated in these recurrent tumors. Accordingly, it is suggested that craniopharyngiomas produce HCG-like peptides and that craniopharyngiomas are unique squamous neoplasms arising in the sellar region from progenitor cells of a neuroendocrine lineage.

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  • 1.

    ArceciRJ,,CroopJM,&HorwitzSB,et al:The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.ProcNatl Acad Sci USA85:43504354,1988Arceci RJ, Croop JM, Horwitz SB, et al: The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.ProcNatl Acad Sci USA 85:4350–4354, 1988

    • Search Google Scholar
    • Export Citation
  • 2.

    AsaSL,,KovacsK,&BilbaoJM,et al:Immunohistochemical localization of keratin in craniopharyngiomas and squamous cell nests of the human pituitary.Acta Neuropathol54:257260,1981Asa SL, Kovacs K, Bilbao JM, et al: Immunohistochemical localization of keratin in craniopharyngiomas and squamous cell nests of the human pituitary.Acta Neuropathol 54:257–260, 1981

    • Search Google Scholar
    • Export Citation
  • 3.

    AtwellWJ:The development of the hypophysis cerebri in man, with special reference to the pars tuberalis.Am J Anat37:159179,1926Atwell WJ: The development of the hypophysis cerebri in man, with special reference to the pars tuberalis.Am J Anat 37:159–179, 1926

    • Search Google Scholar
    • Export Citation
  • 4.

    BannaM:Craniopharyngioma: based on 160 cases.Br J Radiol49:206223,1976Banna M: Craniopharyngioma: based on 160 cases.Br J Radiol 49:206–223, 1976

    • Search Google Scholar
    • Export Citation
  • 5.

    BartlettJR:Craniopharyngiomas. An analysis of some aspects of symptomatology, radiology and histology.Brain94:725732,1971Bartlett JR: Craniopharyngiomas. An analysis of some aspects of symptomatology, radiology and histology.Brain 94:725–732, 1971

    • Search Google Scholar
    • Export Citation
  • 6.

    CarmichaelHT:Squamous epithelial rests in the hypophysis cerebri.Arch Neurol Psychiatry26:966975,1931Carmichael HT: Squamous epithelial rests in the hypophysis cerebri.Arch Neurol Psychiatry 26:966–975, 1931

    • Search Google Scholar
    • Export Citation
  • 7.

    CheethamHD:Experimental squamous metaplasia and squamous epithelioma formation in the pituitary of the rat.Br J Cancer17:657662,1963Cheetham HD: Experimental squamous metaplasia and squamous epithelioma formation in the pituitary of the rat.Br J Cancer 17:657–662, 1963

    • Search Google Scholar
    • Export Citation
  • 8.

    ChenCJ,,ChinJE,&UedaK,et al:Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Cell47:381389,1986Chen CJ, Chin JE, Ueda K, et al: Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.Cell 47:381–389, 1986

    • Search Google Scholar
    • Export Citation
  • 9.

    Cordon-CardoC,,O'BrienJP,&BocciaJ,et al:Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.J Histochem Cytochem38:12771287,1990Cordon-Cardo C, O'Brien JP, Boccia J, et al: Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.J Histochem Cytochem 38:1277–1287, 1990

    • Search Google Scholar
    • Export Citation
  • 10.

    Cordon-CardoC,,O'BrienJP,&CasalsD,et al:Immunoanatomic and immunopathologic expression of the multidrug resistance gene product.Cancer Cells7:8793,1989Cordon-Cardo C、O ' brien JP,卡萨尔斯D,等: Immunoanatomic and immunopathologic expression of the multidrug resistance gene product.Cancer Cells 7:87–93, 1989

    • Search Google Scholar
    • Export Citation
  • 11.

    CritchleyM,&IronsideRN:The pituitary adamantinomata.Brain49:437481,1926Critchley M, Ironside RN: The pituitary adamantinomata.Brain 49:437–481, 1926

    • Search Google Scholar
    • Export Citation
  • 12.

    GoodrichJT,,PostKD,&DuffyP:Ciliated craniopharyngioma.Surg Neurol24:105111,1985Goodrich JT, Post KD, Duffy P: Ciliated craniopharyngioma.Surg Neurol 24:105–111, 1985

    • Search Google Scholar
    • Export Citation
  • 13.

    HamadaH,&TsuruoT:Purification of the 170- to 180- kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180- kilodalton membrane glycoprotein is an ATPase.J Biol Chem263:14541458,1988Hamada H, Tsuruo T: Purification of the 170- to 180- kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180- kilodalton membrane glycoprotein is an ATPase.J Biol Chem 263:1454–1458, 1988

    • Search Google Scholar
    • Export Citation
  • 14.

    HarrisPE,,PerryL,&ChardT,et al:Immunoreactive human chorionic gonadotropin from the cyst fluid and CSF of patients with craniopharyngioma.Clin Endocrinol29:503508,1988Harris PE, Perry L, Chard T, et al: Immunoreactive human chorionic gonadotropin from the cyst fluid and CSF of patients with craniopharyngioma.Clin Endocrinol 29:503–508, 1988

    • Search Google Scholar
    • Export Citation
  • 15.

    HöflerH,,DenkH,&WalterGF:Immunohistochemical demonstration of cytokeratins in endocrine cells of the human pituitary gland and in pituitary adenomas.Virchows Arch [A]404:359368,1984Höfler H, Denk H, Walter GF: Immunohistochemical demonstration of cytokeratins in endocrine cells of the human pituitary gland and in pituitary adenomas.Virchows Arch [A] 404:359–368, 1984

    • Search Google Scholar
    • Export Citation
  • 16.

    IronsideJW,,RoydsJA,&JeffersonAA,et al:Immunolocalisation of cytokeratins in the normal and neoplastic human pituitary gland.J Neurol Neurosurg Psychiatry50:5765,1987Ironside JW, Royds JA, Jefferson AA, et al: Immunolocalisation of cytokeratins in the normal and neoplastic human pituitary gland.J Neurol Neurosurg Psychiatry 50:57–65, 1987

    • Search Google Scholar
    • Export Citation
  • 17.

    JamesonJL,,LindellCM,&HsuDW,et al:Expression of chorionic gonadotropin-β-like messenger ribonucleic acid in anα-subunit-secreting pituitary adenoma.J Clin Endocrinol Metab62:12711278,1986Jameson JL, Lindell CM, Hsu DW, et al: Expression of chorionic gonadotropin-β-like messenger ribonucleic acid in anα-subunit-secreting pituitary adenoma.J Clin Endocrinol Metab 62:1271–1278, 1986

    • Search Google Scholar
    • Export Citation
  • 18.

    KahnEA,,GoschHH,&SeegerJF,et al:Forty-five years experience with the craniopharyngiomas.Surg Neurol1:512,1973Kahn EA, Gosch HH, Seeger JF, et al: Forty-five years experience with the craniopharyngiomas.Surg Neurol 1:5–12, 1973

    • Search Google Scholar
    • Export Citation
  • 19.

    KasperM,&KarstenU:Coexpression of cytokeratin and vimentin in Rathke's cysts of human pituitary gland.Cell Tissue Res253:419424,1988Kasper M, Karsten U: Coexpression of cytokeratin and vimentin in Rathke's cysts of human pituitary gland.Cell Tissue Res 253:419–424, 1988

    • Search Google Scholar
    • Export Citation
  • 20.

    KasperM,,StosiekP,&van MuijenGNP,et al:Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland.Histochemistry93:93103,1989Kasper M, Stosiek P, van Muijen GNP, et al: Cell type heterogeneity of intermediate filament expression in epithelia of the human pituitary gland.Histochemistry 93:93–103, 1989

    • Search Google Scholar
    • Export Citation
  • 21.

    KlibanskiA,,RidgwayEC,&ZervasNT:Pure alpha subunit-secreting pituitary tumors.J Neurosurg59:585589,1983Klibanski A, Ridgway EC, Zervas NT: Pure alpha subunit-secreting pituitary tumors.J Neurosurg 59:585–589, 1983

    • Search Google Scholar
    • Export Citation
  • 22.

    LiszczakT,,理查森EPJr,&PhillipsJP,et al:Morphological, biochemical, ultrastructural, tissue culture and clinical observations of typical and aggressive craniopharyngiomas.Acta Neuropathol43:191203,1978Liszczak T, Richardson EP Jr, Phillips JP, et al: Morphological, biochemical, ultrastructural, tissue culture and clinical observations of typical and aggressive craniopharyngiomas.Acta Neuropathol 43:191–203, 1978

    • Search Google Scholar
    • Export Citation
  • 23.

    LuseSA,&KernohanJW:Squamous-cell nests of the pituitary gland.Cancer8:623628,1955Luse SA, Kernohan JW: Squamous-cell nests of the pituitary gland.Cancer 8:623–628, 1955

    • Search Google Scholar
    • Export Citation
  • 24.

    MatsushimaT,,FukuiM,&OhtaM,et al:Ciliated and goblet cells in craniopharyngioma. Light and electron microscopic study at surgery and autopsy.Acta Neuropathol50:199205,1980Matsushima T, Fukui M, Ohta M, et al: Ciliated and goblet cells in craniopharyngioma. Light and electron microscopic study at surgery and autopsy.Acta Neuropathol 50:199–205, 1980

    • Search Google Scholar
    • Export Citation
  • 25.

    MatsuuraS,,OhashiM,&ChenHC,et al:Physicochemical and immunological characterization of an HCG-like substance from human pituitary glands.Nature286:740741,1980Matsuura S, Ohashi M, Chen HC, et al: Physicochemical and immunological characterization of an HCG-like substance from human pituitary glands.Nature 286:740–741, 1980

    • Search Google Scholar
    • Export Citation
  • 26.

    MollR,,FrankeWW,&SchillerDL,et al:The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.Cell31:1124,1982Moll R, Franke WW, Schiller DL, et al: The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.Cell 31:11–24, 1982

    • Search Google Scholar
    • Export Citation
  • 27.

    PastanIH,&GottesmanMM:Molecular biology of multidrug resistance in human cells, inDe VitaVTJr,,HellmanS,&RosenbergSA(eds):Important Advances in Oncology.Philadelphia:JB Lippincott,1988, pp316Pastan IH, Gottesman MM: Molecular biology of multidrug resistance in human cells, in De Vita VT Jr, Hellman S, Rosenberg SA (eds):Important Advances in Oncology.Philadelphia: JB Lippincott, 1988, pp 3–16

    • Search Google Scholar
    • Export Citation
  • 28.

    PelletierG,,LeclercR,&LabrieF:Identification of gonadotropic cells in the human pituitary by immunoperoxidase technique.Mol Cell Endocrinol6:123128,1976Pelletier G, Leclerc R, Labrie F: Identification of gonadotropic cells in the human pituitary by immunoperoxidase technique.Mol Cell Endocrinol 6:123–128, 1976

    • Search Google Scholar
    • Export Citation
  • 29.

    PetitoCK,,DeGirolamiU,&EarleKM:适应证:临床和病理view.Cancer37:19441952,1976Petito CK, DeGirolami U, Earle KM: Craniopharyngiomas: a clinical and pathological review.Cancer 37:1944–1952, 1976

    • Search Google Scholar
    • Export Citation
  • 30.

    RiordanJR,&LingV:Genetic and biochemical characterization of multidrug resistance.Pharmacol Ther28:5175,1985Riordan JR, Ling V: Genetic and biochemical characterization of multidrug resistance.Pharmacol Ther 28:51–75, 1985

    • Search Google Scholar
    • Export Citation
  • 31.

    RussellDS,&RubinsteinLJ:Pathology of Tumours of the Nervous System,ed 4.Baltimore:Williams & Wilkins,1977Russell DS, Rubinstein LJ:Pathology of Tumours of the Nervous System, ed 4.Baltimore: Williams & Wilkins, 1977

    • Search Google Scholar
    • Export Citation
  • 32.

    ScheperRJ,,BulteJWM,&BrakkeeJGP,et al:Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance.Int J Cancer42:389394,1988Scheper RJ, Bulte JWM, Brakkee JGP, et al: Monoclonal antibody JSB-1 detects a highly conserved epitope on the P-glycoprotein associated with multi-drug-resistance.Int J Cancer 42:389–394, 1988

    • Search Google Scholar
    • Export Citation
  • 33.

    SnyderPJ,,JohnsonJ,&MuzykaR:Abnormal secretion of glycoproteinα-subunit and follicle-stimulating hormone (FSH)β-subunit in men with pituitary adenomas and FSH hypersecretion.J Clin Endocrinol Metab51:579584,1980Snyder PJ, Johnson J, Muzyka R: Abnormal secretion of glycoproteinα-subunit and follicle-stimulating hormone (FSH)β-subunit in men with pituitary adenomas and FSH hypersecretion.J Clin Endocrinol Metab 51:579–584, 1980

    • Search Google Scholar
    • Export Citation
  • 34.

    SugawaraI,,KataokaI,&MorishitaY,et al:Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.Cancer Res48:19261929,1988Sugawara I, Kataoka I, Morishita Y, et al: Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16.Cancer Res 48:1926–1929, 1988

    • Search Google Scholar
    • Export Citation
  • 35.

    SugawaraI,,NakahamaM,&HamadaH,et al:Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr170,000–180,000 P-glycoprotein.Cancer Res48:46114614,1988Sugawara I, Nakahama M, Hamada H, et al: Apparent stronger expression in the human adrenal cortex than in the human adrenal medulla of Mr170,000–180,000 P-glycoprotein.Cancer Res 48:4611–4614, 1988

    • Search Google Scholar
    • Export Citation
  • 36.

    SuginamiH,&KawaoiA:Immunohistochemical localization of a human chorionic gonadotropin-like substance in the human pituitary gland.J Clin Endocrinol Metab55:11611166,1982Suginami H, Kawaoi A: Immunohistochemical localization of a human chorionic gonadotropin-like substance in the human pituitary gland.J Clin Endocrinol Metab 55:1161–1166, 1982

    • Search Google Scholar
    • Export Citation
  • 37.

    TachibanaO,&YamashimaT:Immunohistochemical study of folliculo-stellate cells in human pituitary adenomas.Acta Neuropathol76:458464,1988Tachibana O, Yamashima T: Immunohistochemical study of folliculo-stellate cells in human pituitary adenomas.Acta Neuropathol 76:458–464, 1988

    • Search Google Scholar
    • Export Citation
  • 38.

    YoshidaJ,,KobayashiT,&KageyamaN,et al:Symptomatic Rathke's cleft cyst. Morphological study with light and electron microscopy and tissue culture.J Neurosurg47:451458,1977Yoshida J, Kobayashi T, Kageyama N, et al: Symptomatic Rathke's cleft cyst. Morphological study with light and electron microscopy and tissue culture.J Neurosurg 47:451–458, 1977

    • Search Google Scholar
    • Export Citation

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