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Gamma Knife surgery for convexity, parasagittal, and falcine meningiomas

Clinical article

Toshinori Hasegawa Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Yoshihisa Kida Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Masayuki Yoshimoto Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Hiroshi Iizuka Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Dai Ishii Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Kouta Yoshida Department of Neurosurgery, Gamma Knife Center, Komaki City Hospital, Komaki, Japan

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Object

The aim of this study was to evaluate the outcomes in patients with convexity, parasagittal, or falcine meningiomas treated using Gamma Knife surgery (GKS) and to determine management strategy considering a risk of radiation-induced edema.

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One hundred twelve patients who harbored 125 convexity, parasagittal, or falcine meningiomas were assessed. Forty-six patients underwent GKS as the initial treatment. The median tumor diameter was 25 mm, and median tumor volume was 8 cm3. The median maximum and margin doses were 30 and 16 Gy, respectively.

Results

The median follow-up period was 72 months. The actuarial 5- and 10-year progression-free survival rates were 78% and 55%, respectively. The actuarial 5- and 10-year local tumor control rates were 87% and 71%, respectively. Of 29 tumors that developed postradiosurgical edema, 7 were symptomatic. The actuarial symptomatic radiation-induced edema rate was 7%. The incidence of this complication was significantly higher in patients who underwent GKS as the initial treatment. Six of 46 patients for whom GKS was the initial treatment had preradiosurgical edema. Of these 6 patients, 4 developed severe panhemispheric edema after GKS (2 patients with parasagittal tumors, 1 with a falx tumor, and 1 with a convexity tumor).

Conclusions

Gamma Knife surgery is an effective treatment for convexity, parasagittal, and falcine meningiomas as the initial or adjuvant treatment. However, GKS should be restricted to small- to medium-sized tumors, particularly in patients with primary tumors, because radiation-induced edema is more common in convexity, parasagittal, and falcine meningiomas than skull base meningiomas.

Abbreviations used in this paper:

GKS = Gamma Knife surgery ; LTC = local tumor control ; PFS = progression-free survival .
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  • 1

    BarbaroNM,,GutinPH,,WilsonCB,,ShelineGE,,BoldreyEB,&瓦拉WM:Radiation therapy in the treatment of partially resected meningiomas.开云体育app官方网站下载入口20:525528,1987

    • Search Google Scholar
    • Export Citation
  • 2

    比泽尔M,,WöckelL,,LuftAR,,WakhlooAK,,PetersenD,&OpitzH,et al.:The importance of pial blood supply to the development of peritumoral brain edema in meningiomas.J Neurosurg87:368373,1997

    • Search Google Scholar
    • Export Citation
  • 3

    ChangJH,,ChangJW,,ChoiJY,,ParkYG,&ChungSS:Complications after gamma knife radiosurgery for benign meningiomas.J Neurol Neurosurg Psychiatry74:226230,2003

    • Search Google Scholar
    • Export Citation
  • 4

    ChuangCC,,ChangCN,,TsangNM,,WeiKC,,TsengCK,&ChangJT,et al.:Linear accelerator-based radiosurgery in the management of skull base meningiomas.J Neurooncol66:241249,2004

    • Search Google Scholar
    • Export Citation
  • 5

    CondraKS,,BuattiJM,,MendenhallWM,,FriedmanWA,,MarcusRBJr,&RhotonAL:Benign meningiomas: primary treatment selection affects survival.Int J Radiat Oncol Biol Phys39:427436,1997

    • Search Google Scholar
    • Export Citation
  • 6

    DiBiaseSJ,,KwokY,,YovinoS,,ArenaC,,NaqviS,&TempleR,et al.:Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas.Int J Radiat Oncol Biol Phys60:15151519,2004

    • Search Google Scholar
    • Export Citation
  • 7

    FlickingerJC,,KondziolkaD,,MaitzAH,&LunsfordLD:Gamma knife radiosurgery of imaging-diagnosed intracranial meningioma.Int J Radiat Oncol Biol Phys56:801806,2003

    • Search Google Scholar
    • Export Citation
  • 8

    HasegawaT,,KidaY,,YoshimotoM,,KoikeJ,,IizukaH,&IshiiD:Long-term outcomes of Gamma Knife surgery for cavernous sinus meningioma.J Neurosurg107:745751,2007

    • Search Google Scholar
    • Export Citation
  • 9

    IwaiY,,YamanakaK,&IshiguroT:Gamma knife radiosurgery for the treatment of cavernous sinus meningiomas.开云体育app官方网站下载入口52:517524,2003

    • Search Google Scholar
    • Export Citation
  • 10

    KalapurakalJA,,SilvermanCL,,AkhtarN,,LaskeDW,,BraitmanLE,&BoykoOB,et al.:Intracranial meningiomas: factors that influence the development of cerebral edema after stereotactic radiosurgery and radiation therapy.Radiology204:461465,1997

    • Search Google Scholar
    • Export Citation
  • 11

    DG,,CH,,ChungHT,,PaekSH,,JeongSS,&HanDH,et al.:Gamma knife surgery of superficially located meningioma.J Neurosurg102:Suppl255258,2005

    • Search Google Scholar
    • Export Citation
  • 12

    KollováA,,LiscákR,,NovotnýJJr,,VladykaV,,SimonováG,&JanouskováL:Gamma Knife surgery for benign meningioma.J Neurosurg107:325336,2007

    • Search Google Scholar
    • Export Citation
  • 13

    KondziolkaD,,FlickingerJC,&PerezB:明智的切除和/或放射治疗等gittal meningiomas: outcomes from a multicenter review.开云体育app官方网站下载入口43:405414,1998

    • Search Google Scholar
    • Export Citation
  • 14

    KondziolkaD,,MathieuD,,LunsfordLD,,MartinJJ,,MadhokR,&NiranjanA,et al.:Radiosurgery as definitive management of intracranial meningiomas.开云体育app官方网站下载入口62:5360,2008

    • Search Google Scholar
    • Export Citation
  • 15

    KondziolkaD,,MadhokR,,LunsfordLD,,MathieuD,,MartinJJ,&NiranjanA,et al.:Stereotactic radiosurgery for convexity meningiomas. Clinical article.J Neurosurg111:458463,2009

    • Search Google Scholar
    • Export Citation
  • 16

    LeeJYK,,NiranjanA,,McInerneyJ,,KondziolkaD,,FlickingerJC,&LunsfordLD:Stereotactic radiosurgery providing long-term tumor control of cavernous sinus meningiomas.J Neurosurg97:6572,2002

    • Search Google Scholar
    • Export Citation
  • 17

    MalikI,,RoweJG,,沃尔顿L,,RadatzMW,&KemenyAA:The use of stereotactic radiosurgery in the management of meningiomas.Br J Neurosurg19:1320,2005

    • Search Google Scholar
    • Export Citation
  • 18

    MiralbellR,,LinggoodRM,,de la MonteS,,ConveryK,,MunzenriderJE,&MirimanoffRO:The role of radiotherapy in the treatment of subtotally resected benign meningiomas.J Neurooncol13:157164,1992

    • Search Google Scholar
    • Export Citation
  • 19

    MirimanoffRO,,DosoretzDE,,LinggoodRM,,OjemannRG,&MartuzaRL:Meningioma: analysis of recurrence and progression following neurosurgical resection.J Neurosurg62:1824,1985

    • Search Google Scholar
    • Export Citation
  • 20

    NakasuS,,NakasuY,,NakajimaM,,MatsudaM,&HandaJ:Preoperative identification of meningiomas that are highly likely to recur.J Neurosurg90:455462,1999

    • Search Google Scholar
    • Export Citation
  • 21

    NicolatoA,,ForoniR,,AlessandriniF,,BricoloA,&GerosaM:Radiosurgical treatment of cavernous sinus meningiomas: experience with 122 treated patients.开云体育app官方网站下载入口51:11531161,2002

    • Search Google Scholar
    • Export Citation
  • 22

    NiiroM,,YatsushiroK,,NakamuraK,,KawaharaY,&KuratsuJ:Natural history of elderly patients with asymptomatic meningiomas.J Neurol Neurosurg Psychiatry68:2528,2000

    • Search Google Scholar
    • Export Citation
  • 23

    PollockBE:Stereotactic radiosurgery for intracranial meningiomas: indications and results.Neurosurg Focus14:5e4,2003

  • 24

    RochePH,,PelletW,,FuentesS,,ThomassinJM,&RégisJ:Gamma knife radiosurgical management of petroclival meningiomas results and indications.Acta Neurochir (Wien)145:883888,2003

    • Search Google Scholar
    • Export Citation
  • 25

    RochePH,,RégisJ,,DufourH,,FournierHD,,DelsantiC,&PelletW,et al.:Gamma knife radiosurgery in the management of cavernous sinus meningiomas.J Neurosurg93:Suppl 36873,2000

    • Search Google Scholar
    • Export Citation
  • 26

    RogersL,&MehtaM:Role of radiation therapy in treating intracranial meningiomas.Neurosurg Focus23:4E4,2007

  • 27

    ShinM,,KuritaH,,SasakiT,,KawamotoS,,TagoM,&KawaharaN,et al.:Analysis of treatment outcome after stereotactic radiosurgery for cavernous sinus meningiomas.J Neurosurg95:435439,2001

    • Search Google Scholar
    • Export Citation
  • 28

    SpiegelmannR,,NissimO,,MenhelJ,,AlezraD,&PfefferMR:Linear accelerator radiosurgery for meningiomas in and around the cavernous sinus.开云体育app官方网站下载入口51:13731380,2002

    • Search Google Scholar
    • Export Citation
  • 29

    StaffordSL,,PerryA,,SumanVJ,,MeyerFB,,ScheithauerBW,&LohseCM,et al.:整洁的arily resected meningiomas: outcome and prognostic factors in 581 Mayo Clinic patients, 1978 through 1988.Mayo Clin Proc73:936942,1998

    • Search Google Scholar
    • Export Citation
  • 30

    StaffordSL,,PollockBE,,FooteRL,,LinkMJ,,GormanDA,&SchombergPJ,et al.:Meningioma radiosurgery: tumor control, outcomes, and complications among 190 consecutive patients.开云体育app官方网站下载入口49:10291038,2001

    • Search Google Scholar
    • Export Citation
  • 31

    TaylorBWJr,,MarcusRBJr,,FriedmanWA,,博林格WEJr,&MillionRR:The meningioma controversy: postoperative radiation therapy.Int J Radiat Oncol Biol Phys15:299304,1988

    • Search Google Scholar
    • Export Citation
  • 32

    瓦拉WM,,ShelineGE,,NewmanH,,TownsendJJ,&BoldreyEB:Radiation therapy of meningiomas.Am J Roentgenol Radium Ther Nucl Med123:453458,1975

    • Search Google Scholar
    • Export Citation
  • 33

    YoshiokaH,,HamaS,,TaniguchiE,,SugiyamaK,,AritaK,&KurisuK:瘤旁的大脑edema associated with meningioma: influence of vascular endothelial growth factor expression and vascular blood supply.Cancer85:936944,1999

    • Search Google Scholar
    • Export Citation
  • 34

    ZachenhoferI,,WolfsbergerS,,AichholzerM,,BertalanffyA,,RoesslerK,&KitzK,et al.:对颅基meningio伽玛刀放射治疗mas: experience of tumor control, clinical course, and morbidity in a follow-up of more than 8 years.开云体育app官方网站下载入口58:2836,2006

    • Search Google Scholar
    • Export Citation

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