Jonathan PindrikDepartment of Pediatric Neurosurgery, Nationwide Children’s Hospital, Columbus; and Department of Neurosurgery, The Ohio State University, Columbus, Ohio
Mark DamanteDepartment of Pediatric Neurosurgery, Nationwide Children’s Hospital, Columbus; and Department of Neurosurgery, The Ohio State University, Columbus, Ohio
Lauren SchulzDepartment of Pediatric Neurosurgery, Nationwide Children’s Hospital, Columbus; and Department of Neurosurgery, The Ohio State University, Columbus, Ohio
Ammar ShaikhouniDepartment of Pediatric Neurosurgery, Nationwide Children’s Hospital, Columbus; and Department of Neurosurgery, The Ohio State University, Columbus, Ohio
Jeffrey R. LeonardDepartment of Pediatric Neurosurgery, Nationwide Children’s Hospital, Columbus; and Department of Neurosurgery, The Ohio State University, Columbus, Ohio
Seizures can be a debilitating manifestation of underlying neoplastic intracranial pathology. Existing literature offers a paucity of scientific consensus regarding risk factors, seizure semiology, operative techniques, and tumor characteristics in pediatric patients with a concurrent diagnosis of primary intracranial neoplasm and seizures. To address the limited evidence in current literature, the authors systematically reviewed published literature on current clinical characteristics and management strategies for patients presenting concurrently with seizures and a newly diagnosed brain lesion, while aiming to synthesize a potential management protocol or set of recommendations for these patients.
开云体育世界杯赔率
An initial search revealed 792 papers, of which 196 studies were excluded, leaving 596 studies available for abstract review. After further stratification, 546 studies were eliminated, leaving 50 studies for eligibility assessment. Of the 50 studies, 12 met the criteria for outcome extraction.
RESULTS
The results indicate that patients with a mean age of 9 years with a newly diagnosed brain tumor and presenting symptoms of seizure are likely to present with daily seizures of the complex partial subtype, with the most likely primary epileptogenic and neoplastic foci occurring in the temporal lobe. The most common tumor subtypes were low-grade gliomas, ganglioglioma, dysembryoplastic neuroepithelial tumor, or astrocytoma. With the aim of gross-total resection, 77.54% of patients are likely to achieve seizure freedom.
CONCLUSIONS
This study highlights the demographic, clinical, seizure, tumor, and postoperative outcomes for pediatric patients presenting with a primary brain tumor and concurrent seizures. Further prospective multicenter studies are necessary to understand and compare varying treatment approaches and to develop standardized guidelines for these patients, with the goal of optimizing neuro-oncological and seizure-related outcomes.
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